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Top of pageDiscussionWe have demonstrated that both ET-1 and ET-3 induce the secretion of CXCL1 and CXCL8 proteins in human melanoma cells. This induction occurs within hours of ET-1 exposure and remains elevated over an extended time course. CXCL1 and CXCL8 secretion can be blocked by the selective ETB antagonist BQ788 but not by the selective ETA antagonist BQ610. BQ610 and BQ788 are cyclic peptides that function as competitive inhibitors of the ETA and ETB receptors, respectively (Huggins and Pelton, 1997).
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